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butabarbital will lower the level or result of artemether/lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Tricyclic Antidepressants: Barbiturates might increase the metabolism of Tricyclic Antidepressants. Administration: Check for lessened efficacy of tricyclic antidepressants if a barbiturate is